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今日要闻!维立志博-B(09887)：维利信?(奥帕替苏米单抗，PD-L1/4-1BB双特异性抗体，LBL-024)一线治疗NSCLC的Ⅱ期临床研究摘要在WCLC网站发布

2026-08-20 09:02:44来源：智通财经  


(资料图片仅供参考)

智通财经APP讯，维立志博-B(09887)发布公告，公司自主研发的在研药物维利信(奥帕替苏米单抗，PD L1/4–1BB双特异性抗体)联合化疗一线治疗非小细胞肺癌(NSCLC)的Ⅱ期临床研究摘要全文，已在世界肺癌大会(WCLC)官网正式发布。基于截至2026年3 月6日的资料分析，维利信联合化疗在整体人群中展现出令人鼓舞的客观缓解率(ORR)，而在鳞癌与非鳞癌亚组均观察到强劲的缩瘤效应。摘要所披露的数据基于仅3.6个月的随访，而随访时间超过七个月的最新数据将于2026年9月14日在WCLC口头报告环节公布。

摘要资料显示，维利信联合化疗一线治疗局部晚期或转移NSCLC在60例疗效可评估的患者中，ORR达65.0%、疾病控制率(DCR)达95.0%。在鳞癌亚组，ORR 为77.4%、DCR为96.8%，非鳞癌亚组的ORR则为51.7%、DCR为93.1%。整体安全性可控，且未观察到新的安全信号。

摘要披露的数据为首次递交时随访3.6个月的数据。WCLC现场将公布的随访超过七个月的数据将对此前发现进行进一步验证。随着随访时间延长，数据持续成熟，响应深度持续加深，无进展生存期(PFS)获益趋势亦持续增强，以上结果共同支持维利信独特的“松剎车和踩油门”双靶点免疫协同机制有望为 NSCLC确立全新的IO 2.0治疗路径。目前，维利信正在开展11项临床研究，已在多个适应症中展现出明确且积极的疗效信号。前7项适应症的临床数据均展现出潜在同类最佳(BIC)的治疗前景。

责任编辑：hnmd003

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